Chicago, circa 2077
Operation: Reclamation (a.k.a. Land Grab)
Chicago, once known as the Windy City, fell hard when an astral threat emerged and someone decided to detonate a tactical nuclear device downtown. This changed Chicago into Bug City for many years. Insect spirits threatened to overrun the whole Sixth World but it began and stopped with Chicago. Application of a magic eating bacteria eliminated much of the bug threat along with nearly every other dual-natured creature in the city. Chicago politicians had no choice but to establish a quarantine zone.